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The LIDODERM patch is composed of an adhesive material, containing 5% Lidocaine (700mg) in an aqueous base.3 LIDODERM is thought to work by penetrating the skin and binding to receptors within the dermis.4 It is suggested that lidocaine binds to the receptors within the sodium channel, blocking the influx of sodium ions.4 It is believed that this stabilizes the neuronal activity by interrupting the pain signal and reducing the potential for central sensitization.3,4,5 The exact mechanism of action of LIDODERM is not known. The LIDODERM patch can also provide a mechanical barrier against clothing and breezes.4


References

  1. Cluff RS, Rowbotham MC. Pain caused by herpes zoster infection. Neurol Clin. 1998;16(4):813-832.
  2. Weaver BA. The burden of herpes zoster and postherpetic neuralgia in the United States. J Am Osteopath Assoc. 2007;107(suppl 1):S2-S7.
  3. LIDODERM® Complete Prescribing Information. Chadds Ford, PA: Endo Pharmaceuticals; 2010.
  4. Galer BS. Today's Therapeutic Trends. 2000;18:1-20.
  5. Argoff CE. Curr Pain Headache Rep. 2003;7(1):34-38.