Localized Therapy With Very Little Lidocaine Absorption Into the Bloodstream When Using 3 Patches Daily1,2
Systemic adverse reactions following appropriate use of LIDODERM® (lidocaine patch 5%) are unlikely because very little lidocaine is absorbed into the bloodstream—even with 3 patches daily.1,2
In a pharmacokinetic study in which 15 healthy volunteers wore 3 LIDODERM patches for 12 hours on 3 successive days, lidocaine concentrations did not accumulate and stayed below the expected toxicity level of 5 micrograms per milliliter.2
SELECTED SAFETY INFORMATION
- Patients with severe hepatic disease are at greater risk of developing toxic blood concentrations of lidocaine, because of their inability to metabolize lidocaine normally. LIDODERM® should be used with caution in patients receiving Class I antiarrhythmic drugs (such as tocainide and mexiletine) since the toxic effects are additive and potentially synergistic. LIDODERM should also be used with caution in pregnant (including labor and delivery) or nursing mothers.
- When LIDODERM is used concomitantly with local anesthetic products, the amount absorbed from all formulations must be considered.
- Longer duration of application, application of more than the number of recommended patches, smaller patients, or impaired elimination may all contribute to increasing concentrations of lidocaine.1